This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What’s more, this Expert Consult Premium Edition includes access to the complete contents of the book online, fully searchable and updated quarterly by Dr. Hoffman himself.A multidisciplinary approach from a unique team of specialists delivers well-rounded guidance on every topic.
“Red boxes” present the authors’ unique personal strategies for diagnosis and treatment.
An intuitively re-designed table of contents makes information easier than ever to find.
Online access allows you to rapidly search the entire contents of the book.
Regular online updates personally overseen by Dr. Hoffman keep you apprised of important new developments.
Ten cutting-edge new chapters – on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more – keep you completely current.
More than 1,000 vibrant images, all presented in full color for the first time, include a collection of detailed photomicrographs in several chapters selected by a hematopathology image consultant.
An enhanced clinical focus makes actionable information easier to find and apply.
Enhanced coverage of pediatric hematology reflects the supervision of new section editor Helen Heslop, MD, FRCPA, FRACP.
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This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with ? and ? thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.













